男性和女性的酒精消费和意外心力衰竭
Hailun Qin1, Bart J van Essen1, Jozine M Ter Maaten1
1Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
European journal of heart failure
|January 21, 2025
概括
适度饮酒可能会降低心力衰竭风险,但酒消费,尤其是女性,会增加心力衰竭风险. 这项研究澄清了酒精.
科学领域:
- 心血管医学 心血管医学
- 流行病学 流行病学
- 酒精研究 酒精研究
背景情况:
- 过度饮酒与与酒精有关的心肌病和心力衰竭 (HF) 有关.
- 酒精摄入量与HF风险之间的确切剂量反应关系,以及按性别和饮料类型的变化,仍然不清楚.
研究的目的:
- 调查酒精消费与发生心力衰竭 (HF) 之间的联系.
- 根据性别和饮用酒精饮料的类型来研究这种关联的潜在差异.
主要方法:
- 利用了来自407,014名没有先前HF的参与者的英国生物库数据.
- 采用竞争风险模型和立方线回归来分析酒精消耗和HF风险.
- 经过多项潜在混因素的调整,在平均12年的随访期内.
主要成果:
- 在男性和女性中观察到总酒精消耗和事件HF之间的J形关联.
- 低于28单位/周的酒精消费显示出HF风险降低,男性每周14个单位,女性每周7个单位.
- 酒消费,特别是女性 (每周7-14个单位),与HF风险 (29%) 的显著增加有关.
结论:
- 低至中度的总酒精消费可能与患心力衰竭的风险降低有关.
- 酒消费对发生性心力衰竭的风险更高,特别是在女性中.
- 研究结果强调了在评估与酒精有关的心血管风险时考虑饮料类型和性别的重要性.
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