甲醇酸鼻喷雾剂用于剖腹产后止痛和孕乳素分泌
Jingzheng Zeng1, Xiaoqin Sun1, Mingyan Luo2
1Department of Anesthesiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
概括
甲醇鼻喷剂在剖腹产后提供有效的疼痛缓解,减少了阿片类药物的使用. 这种非侵入性方法可以提供早期的术后止痛,而不会影响益生素水平或母乳养的开始.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 产科 产科 产科 产科 产科
背景情况:
- 布托芬醇是剖腹产后疼痛的常见止痛药,通常通过注射给药.
- 鼻腔内布托尔醇的使用较少,为研究提供了一个领域.
- 产后疼痛管理和荷尔蒙影响是母亲护理的关键方面.
研究的目的:
- 评估Butorphanol鼻喷雾在宫收缩疼痛剖腹产后的疗效.
- 为了比较鼻腔内注布托尔法与静脉内注布托尔法的止痛和镇静作用.
- 为了研究布托芬醇对产后益生菌分泌物的影响.
主要方法:
- 经过剖腹产的120名患者被随机分为三个组:鼻内盐水,鼻内布托芬醇 (BI) 和静脉注射布托芬醇 (BV).
- 疼痛和镇静水平使用视觉模拟量表 (VAS) 和拉姆齐镇静量表 (RASS) 在术后6,12和24小时进行评估.
- 记录了母乳养开始时间,阿片类药物消耗和血清前素水平.
主要成果:
- 与对照组相比,内鼻和静脉注射布托芬醇组在6小时内显示出明显较低的VAS得分和较高的RASS得分.
- 与静脉注射方式相比,鼻腔内注射布托尔法的总体消耗要求较低.
- 虽然在早期的术后有效,但12小时内鼻入布托尔巴诺的止痛和镇静作用比静脉输入途径更为明显. 两组之间没有观察到益乳素水平或母乳养开始的显著差异.
结论:
- 布托芬醇鼻喷剂为剖腹产患者提供了令人满意的早期术后止痛.
- 鼻喷雾提供了一个舒适的,非侵入性的替代方案,减少了阿片类药物消费.
- 鼻内注射的布托芬醇似乎不会影响产后的益生菌水平,也不会延迟母乳养的开始.
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