希腊 Vulvovaginal Candidiasis 的流行病学:为期两年的单中心研究
Vasiliki Kroustali1,2,3, Esmeralda Resoulai1,2,3, Lamprini Kanioura3
1Clinical Microbiology Laboratory, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Mycoses
|January 21, 2025
概括
Vulvovaginal candidasis (VVC) 在希腊很常见,其中Candida albicans是最常见的原因. 对可纳的耐药性日益增加,特别是在长菌 (Nakaseomyces glabratus) 中,需要量身定制的抗真菌治疗.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 希腊的 Vulvovaginal Candidiasis (VVC) 流行病学报告不足.
- 过时的数据需要进行当前的流行病学评估.
研究的目的:
- 在希腊症状患者中进行两年后期的VVC调查.
- 分析流行病学方面,物种分布和抗真菌耐药性模式.
主要方法:
- 收集了雅典怀疑VVC的女性的高阴道拭子.
- 使用MALDI-ToFMS识别了Candida物种,并确定了体外敏感性.
- 分析了使用统计测试的易感因素和流行病学趋势.
主要成果:
- 在233名患者中发生了283次VVC发作;患病率为18%.
- 最常见的是Candida albicans (50%),其次是Candida parapsilosis SS (35%) 和Nakaseomyces glabratus (10%) 这两种菌种.
- 在C. albicans中,可纳耐药性为4%,在N. glabratus中为23%,随着N. glabratus VVC和耐药性的增加.
结论:
- VVC在希腊很普遍,主要是由C. albicans,C. parapsilosis SS和N. glabratus引起的.
- 在N. glabratus菌株中高可纳耐药性突显出需要特定的抗真菌策略.
- 新出现的耐药性模式需要持续的监测和有针对性的治疗方法.
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