吸烟模式和严重SARS-CoV-2感染的结果:一个回顾性队列研究
Branko Beronja1, Aleksandra Karan2, Biljana Lukic2
1Faculty of Medicine, University of Belgrade.
吸烟超过40年或每天超过22支香烟显著增加了SARS-CoV-2患者的重症监护室 (ICU) 死亡风险. 戒烟对于预防COVID-19死亡至关重要.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 严重的急性呼吸系统综合征-冠状病毒-2 (SARS-CoV-2) 感染带来了显著的死亡风险,特别是在脆弱人群中.
- 吸烟是已知的呼吸道疾病的风险因素,但它对SARS-CoV-2在重症监护机构的死亡率的具体影响需要进一步调查.
研究的目的:
- 为了调查吸烟习惯 (香烟数量和持续时间) 与因SARS-CoV-2感染而住院于重症监护室 (ICU) 的患者的死亡率之间的联系.
主要方法:
- 追溯队列研究分析了2021年3月至2023年3月期间住院患有严重SARS-CoV-2感染的307名患者的电子病历.
- 数据包括吸烟状态,每日吸烟量和吸烟持续时间. 统计分析包括卡普兰-梅尔生存曲线和接收器运行特征 (ROC) 曲线.
主要成果:
- 分析的患者中有40.7%是目前的吸烟者,吸烟者与非吸烟者相比,患有更高的ICU入院率和死亡率.
- 长时间的吸烟持续时间独立地与SARS-CoV-2的ICU死亡率增加有关.
- >40岁以上的吸烟患者死亡的几率为73.9%;吸烟22.5支/天的患者患重症监护室死亡率为75.4%.
结论:
- 吸烟是严重的SARS-CoV-2感染需要ICU护理的患者死亡的重要预测因素.
- 吸烟的持续时间和强度都与较差的生存结果有关.
- 预防和戒烟干预措施对于减轻与SARS-CoV-2相关的死亡率至关重要.
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