探索先发性痴呆症:了解主观认知衰退的特征加上来自印度的特征
Monisha S1, Dwaiti Roy1, Anjana J Menon1
1Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India.
Journal of Alzheimer's disease : JAD
|January 21, 2025
概括
主观认知衰退加 (SCD+) 表明阿尔茨海默氏症风险较高. SCD+个体显示记忆力和语言技能较差,大脑体积减少,这表明早期的AD指标.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 认知科学 认知科学
背景情况:
- 主观认知衰退 (SCD) 是一种在客观衰退之前的早期先发症综合征.
- 根据SCD加 (SCD+) 标准,可以确定有轻度认知障碍和阿尔茨海默病 (AD) 风险增加的个体.
- 研究SCD+进展有助于早期诊断和治疗痴呆的干预策略.
研究的目的:
- 检查符合SCD+标准的个体的神经认知变化.
- 在老年人群中研究与SCD+相关的神经图像相关的相关物质.
主要方法:
- 对符合SCD+标准的SANSCOG和TLSA队列中的94名参与者的分析.
- 使用曼-惠特尼U测试,将SCD+参与者与健康对照进行比较.
- 回归分析以评估SCD+与认知功能之间的关联.
主要成果:
- SCD+组在情节性记忆延迟回忆,名字面部识别和字母流利性任务中表现较差.
- 一般化的线性模型表明,SCD+组的左大脑皮层和右下皮层体积减少.
- 在记忆,面部识别和口语流性任务中观察到有统计学意义的差异.
结论:
- SCD+参与者表现出记忆和语言能力受损,以及区域大脑体积减少.
- 研究结果表明,SCD+与早期阿尔茨海默病具有共同的特征.
- SCD+ 档案可以帮助早期识别阿尔茨海默病.
更多相关视频
06:58Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
Published on: January 24, 2020
7.3K
06:23The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
Published on: October 13, 2016
32.2K
相关概念视频
Cognitive Development During Adulthood
49
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
49
Dementia
93
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
93
Alzheimer's Disease: Overview
439
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
439
Negative and Cognitive Symptoms of Schizophrenia
41
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
41
Cognitivism
1.4K
Cognitive psychology emerged as a significant field in the mid-20th century. It focused on understanding humans' internal mental processes. This approach emphasizes how people perceive, remember, think, and solve problems—elements critical to human cognition.
Previously dominated by behaviorism, which prioritized observable behaviors and largely ignored mental processes, psychology transformed in the 1950s. Cognitive psychologists argue that understanding how we think and process...
Previously dominated by behaviorism, which prioritized observable behaviors and largely ignored mental processes, psychology transformed in the 1950s. Cognitive psychologists argue that understanding how we think and process...
1.4K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
95
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
95
