最近的压力生活事件与大脑结构之间的关联:英国生物银行纵向MRI研究
Cheryl R Z See1, Annabel X Tan2, Lucia R Valmaggia3,4,5
1Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
概括
最近的压力生活事件 (SLE) 可能不会直接加速老年人大脑体积的下降. 相反,SLE可能会通过抑郁症等情感障碍影响大脑结构.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 衰老研究研究 衰老研究
背景情况:
- 最近的生活压力事件 (SLE) 是精神疾病的已知风险因素.
- 动物研究和一些人类研究表明,压力可以减少灰色物质 (GM) 的体积.
- 对压力和大脑结构变化的纵向研究是有限的.
研究的目的:
- 调查最近的SLE与老年人大脑结构变化之间的纵向关联.
- 检查抑郁症和童年逆境在这种关系中的适度作用.
主要方法:
- 利用了来自4543名参与者的英国生物库纵向数据 (平均年龄为61.5岁).
- 使用FreeSurfer管道分析了结构神经成像数据.
- 专注于总的转基因体积和特定的大脑区域 (海马体,杏仁体,ACC,OFC,insula).
主要成果:
- 最近经历SLE的个体显示,随着时间的推移,海马体积下降的速度较慢.
- 抑郁症减轻了这种影响,抑郁症患者在最近的SLE后显示出较小的GM体积.
- 童年逆境并没有显著地调节SLEs和大脑结构之间的关系.
结论:
- 最近的SLE似乎没有直接加速老年人大脑体积的下降.
- 压力可能通过情绪障碍,特别是抑郁症间接影响大脑结构.
- 需要对年轻人群和与压力相关的特定大脑区域进行进一步的研究.
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