奖励和抑制控制网络之间的功能和有效连接是亚临床暴饮暴食的基础
Ximei Chen1, Wei Li1, Yijun Luo1
1Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China.
The British journal of psychiatry : the journal of mental science
|January 21, 2025
概括
过度饮食的个体在奖励和控制区域之间显示出较弱的大脑连接. 这种与冲动性相关的连接障碍预测了未来的暴饮暴食频率,有助于早期识别.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 越来越多的证据将异常的认知控制和奖励敏感性神经回路与暴饮暴食联系起来.
- 了解大脑系统之间的动态相互作用对于暴饮暴食研究至关重要.
研究的目的:
- 在亚临床暴饮暴食中研究大脑奖励 (自下而上) 和抑制控制 (自上而下) 系统之间的动态相互作用.
- 探索近端风险因素和暴饮暴食的神经支.
- 评估神经指数对未来饮食失调和体重的预测能力.
主要方法:
- 功能性磁共振成像 (fMRI) 数据来自30名暴饮暴食者和29名对照者在食物奖励Go/NoGo任务期间.
- 动态因果建模 (DCM) 用于分析奖励和执行控制区域之间的定向连接的群体间差异.
- 探索近位风险因素和暴饮暴食的神经基础.
主要成果:
- 与对照组相比,暴饮暴食者表现出较低的奖励抑制同步 (例如,中间轨道前皮层[mOFC]-上侧状回环[SPG]连接) .
- 特征冲动性被确定为一个近接因素,削弱了mOFC-SPG连接,加剧了暴饮暴食.
- 核心mOFC-SPG连接性预测了未来6个月的暴饮暴食频率.
结论:
- 这些发现突出了皮质奖励和前对面控制回路之间的自下而上相互作用在亚临床暴饮暴食中的关键作用.
- 提供了对有问题的饮食行为背后的等级神经机制的新见解.
- 暗示了早期识别具有显著暴饮暴食症状的个体的潜力.
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