对非转移性乳腺癌辅助药物治疗中的患者偏好研究的系统审查:属性选择
Ali Homayouni1, Shekoufeh Nikfar1, Fariborz Mokarian Rajabi2
1Department of Pharmacoeconomics and Pharmaceutical Administration, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Iranian journal of pharmaceutical research : IJPR
|January 21, 2025
概括
本综述强调了患者对早期乳腺癌辅助治疗的关键偏好. 副作用,疾病复发预防和治疗方案是影响患者选择的关键因素.
科学领域:
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
- 行为科学 行为科学
背景情况:
- 乳腺癌是一个重大的健康挑战,需要有效的以患者为中心的治疗策略.
- 了解患者对辅助治疗的偏好对于优化治疗决策和改善治疗结果至关重要.
- 激素受体阳性,HER2阴性早期乳腺癌需要根据患者的价值考虑量身定制的治疗方法.
研究的目的:
- 系统地审查和确定影响患者偏好早期乳腺癌辅助治疗的关键因素.
- 综合从离散选择实验研究中关于患者在治疗属性方面的优先事项的发现.
- 为医疗保健决策者提供信息,并指导制定以患者为中心的治疗计划.
主要方法:
- 在PubMed,Embase,科学网和Scopus (2000-2023) 的系统文献搜索.
- 包括最初的英语文章,报告患者在辅助乳腺癌治疗中的偏好.
- 叙事综合和描述统计,用于分析提取的属性和研究特征.
主要成果:
- 在美国,加拿大和荷兰进行的四项研究符合纳入标准.
- 经常报告的属性包括副作用,疗效和治疗方案.
- 在离散选择实验中确定的关键属性是副作用,5年无侵袭性疾病生存率 (iDFS) 和治疗方案.
结论:
- 副作用,5年iDFS和治疗方案是乳腺癌离散选择实验研究的关键属性.
- 联合分析可以增强选择最佳治疗方案并改善患者的坚持.
- 在偏好诱导中取得强有力的结果需要遵守实验设计和数据分析准则.
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