细胞外基质在心脏再生中的作用
Xiying Wang1,2,3,4, Shuo Yu5, Lan Xie1,2,6,4
1Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Heliyon
|January 21, 2025
概括
细胞外基质 (ECM) 为心脏细胞提供结构支持和信号. 了解其在机械传导中的作用是开发新的心脏修复疗法的关键.
科学领域:
- 心血管生物学 心血管生物学
- 生物医学工程 生物医学工程
- 组织工程是组织工程.
背景情况:
- 细胞外基质 (ECM) 是一个动态支架,对心脏平衡至关重要,通过生物化学和机械信号调解细胞与细胞的通信.
- 该ECM通过将机械线索转化为生物化学信号来调节重要的细胞过程,如迁移,粘附,生长,分化,增殖和亡.
- 虽然过度的ECM沉积会导致心脏纤维化,功能障碍和心力衰竭,但新出现的证据强调了它在心脏再生中的潜在作用.
研究的目的:
- 提供关于细胞外基质参与心脏再生的全面审查.
- 探索ECM在心脏修复中的作用的机械和生化方面.
- 突出了解ECM机械传导对治疗进步的潜力.
主要方法:
- 对现有信息和新发现的文献综述.
- 分析ECM对心脏功能的机械和生化贡献.
- 综合当前关于ECM在心脏损伤和再生中的作用的知识.
主要成果:
- ECM对于维持心脏结构和功能至关重要,通过机械传导调节细胞行为.
- 功能障碍的ECM有助于心脏纤维化和心脏衰竭.
- 电心膜在促进受伤后心脏再生方面发挥着重要的,但复杂的作用.
结论:
- 了解细胞外矩阵在心脏平衡和再生中的双重作用至关重要.
- 研究ECM机械传导通路为新的心脏修复策略提供了有前途的途径.
- 针对ECM具有很大的潜力,可以推进心脏再生和治疗心脏病的治疗方法.
相关概念视频
The Extracellular Matrix
8.8K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
8.8K
Extracellular Matrix
2.7K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
2.7K
Cell-matrix's Response to Mechanical Forces
2.5K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
2.5K
Overview of Cell-Matrix Interactions
7.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.0K
Structure of Cardiac Muscles
8.2K
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
8.2K
Role of Matrix Metalloproteases in Degradation of ECM
2.3K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.3K


