微生物发酵对中国洋多糖的抗炎活性的影响
Jinchu Yang1, Yi Zheng2, Yongfeng Yang1
1Technology Center, China Tobacco Henan Industrial Co., Ltd., Zhengzhou, China.
Frontiers in nutrition
|January 21, 2025
概括
用乳酸菌植物M616发酵中国山多糖 (CYPs) 增强了它们的抗炎性质. 由此产生的CYP-LP显示了巨细胞中炎症标志物的改善调节,表明其作为功能性食品成分的潜力.
科学领域:
- 生物化学 生化学
- 食品科学 食品科学 食品科学
- 免疫学 免疫学 免疫学
背景情况:
- 中国洋多糖 (CYPs) 以其潜在的健康益处而闻名.
- 乳酸菌植物菌M616是一种具有已知的生物活性的益生菌.
- 了解发酵对多糖体结构和功能的影响对于开发新型功能成分至关重要.
研究的目的:
- 为了研究乳酸菌植物菌M616发酵对中国洋多糖体 (CYPs) 的化学成分,结构和抗炎活性的影响.
- 为了比较发酵的CYP (CYP-LP) 与未发酵的CYP (CYP-NF) 的抗炎作用.
主要方法:
- 在发酵过程中,使用 Lactobacillus plantarum M616.6 的方法发酵了 CYP.
- 在发酵前后分析化学成分 (碳水化合物,蛋白质,多,单糖) 和分子量.
- 在体外抗氧化活性使用DPPH,ABTS,基和超氧化基清除试验进行了评估.
- 通过测量炎症介质,在脂聚糖诱导的RAW 264.7巨细胞中评估了抗炎活性.
主要成果:
- 发酵增加了CYP中的碳水化合物含量,而蛋白质和多含量基本保持不变.
- 通过发酵,CYP的单糖组成和分子量发生了变化.
- 与未发酵的CYP (CYP-NF) 相比,发酵的CYP (CYP-LP) 显示出更高的抗炎活性.
- CYP-LP有效调节了巨细胞中关键炎症标记物和抗氧化酶的释放.
结论:
- 乳酸菌植物菌M616发酵显著改变了中国山多糖的特性.
- 发酵CYP (CYP-LP) 显示出增强的抗炎作用,使其成为制药和功能性食品应用的有希望的候选人.
更多相关视频
10:02Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
Published on: June 2, 2023
1.9K
07:20Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
Published on: August 23, 2024
438
相关概念视频
Microbes in Food Production
Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
Microbes in Beverage Production
Alcoholic beverages such as wine, beer, and spirits are the products of microbial fermentation processes that transform simple sugars into ethanol and a wide array of complex flavor compounds. These transformations rely on the metabolic activities of specific yeasts and bacteria, which are selected and controlled to yield the desired beverage characteristics.Wine Fermentation and MaturationWine production begins with the crushing of grapes to release juice and pulp, forming a must that is...
Microbes in the Production of Fermented Foods
Lactic acid bacteria (LAB) and molds are instrumental in fermenting plant-based foods to enhance preservation and ensure year-round availability. These microbial processes convert plant carbohydrates into organic acids and other metabolites that inhibit spoilage organisms and contribute to the sensory qualities of the final product.In sauerkraut production, cabbage goes through a microbial succession that starts with cocci such as Leuconostoc mesenteroides. These microbes begin fermentation by...
Production of Organic Acids
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
