妊娠年龄对死性肠球炎相关肠道穿孔临床特征的影响
Minming Chen1, Wei Feng1, Jinping Hou1
1Department of General & Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China.
Frontiers in pediatrics
|January 21, 2025
概括
新生儿死性肠球炎相关肠孔 (NEC-IP) 根据妊娠年龄 (GA) 显示出不同的临床特征. 妊娠年龄,败血症,凝血病,先天性心脏病和患病的肠道段是不良结果的关键预测因素.
科学领域:
- 新生儿手术 新生儿手术
- 儿科胃肠病学 儿科胃肠病学
- 临床新生儿学 临床新生儿学
背景情况:
- 结核性肠球炎相关的肠孔 (NEC-IP) 是新生儿的一种严重并发症.
- 了解不同妊娠年龄 (GA) 的临床变异和预后因素对于优化护理至关重要.
研究的目的:
- 根据妊娠年龄分层的新生儿中研究NEC-IP的临床特征.
- 确定与这些婴儿预后不佳相关的独立风险因素.
主要方法:
- 对113个NEC-IP案件进行了回顾性分析.
- 根据GA,患者被分为三个组:早期 (28-<32周),中期 (32-<34周) 和晚期 (34-<37周).
- 分析了临床数据,并发症,手术发现,治疗方法和结果;使用回归分析确定了不良预后的风险因素.
主要成果:
- 1组 (早期的GA) 与2组相比,出生时体重较低,NEC和手术的发病时间较晚.
- 1组的败血症,凝血病,先天性心脏病 (CHD) 和低蛋白血症的发病率高于2组,呼吸衰竭/低蛋白血症的发病率高于3组.
- 第1组还增加了血管活性物质的使用和机械通风.
- 确定了不良预后的独立风险因素:下GA,败血症,凝血病,心脏病,以及患病的肠段的程度.
结论:
- 根据妊娠年龄,NEC-IP的临床特征显著变化,影响手术时间和并发症.
- 妊娠年龄,败血症,凝血病,先天性心脏病和肠道干扰的程度是NEC-IP患者预后不佳的关键独立预测因素.
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