三糖糖指数和肥胖指标与多种慢性疾病的关联:基于查尔斯的纵向队列研究
Yincai Lan1, Guangzi Qi1, Boya Li1
1School of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People's Republic of China.
三甘油糖 (TyG) 指数和相关的肥胖指标与多种慢性疾病 (MCD) 的更高风险有关. 监测这些标志物可以帮助预防和管理MCD.
科学领域:
- 代谢健康和慢性疾病流行病学.
- 发现用于疾病风险评估的生物标志物.
背景情况:
- 多重慢性疾病 (MCD) 构成了全球重大健康负担.
- 识别MCD风险的早期指标对于预防策略至关重要.
研究的目的:
- 调查三糖糖 (TyG) 指数,综合肥胖指数和MCD发病率之间的关联.
- 建立基于这些标志物的MCD预防和治疗的基础.
主要方法:
- 来自中国健康与退休长度研究 (2011-2015年) 的3037名参与者的分析.
- 根据TyG,TyG-BMI,TyGWC和TyGWHtR指数对四分位数进行分类.
- 利用考克斯的比例危险模型,受限立方线回归和ROC曲线分析来评估风险和预测能力.
主要成果:
- 在TyG,TyG-BMI,TyG-WC和TyG-WHtR指数的最高四分位数 (Q4) 中观察到MCD的风险增加.
- 在TyG指数和MCD风险之间发现了线性剂量反应关系.
- 在TyG-BMI,TyG-WC和TyG-WHtR指数与MCD风险之间确定了非线性剂量反应关系.
结论:
- 泰格指数及其肥胖综合指数 (TyG-BMI,TyG-WC,TyG-WHtR) 与患上多发性疾病的风险增加有关.
- 定期测量和管理这些指数可以有助于预防和控制MCD.
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