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在患有自闭症谱系障碍的成年人中,使用近红外光谱测量了降低的前额血动力学反应

Kohei Kamikawa¹, Kazuhiko Yamamuro^1,2, Ryo Mizui¹

¹Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.

Frontiers in psychiatry

|January 21, 2025

概括

患有自闭症谱系障碍 (ASD) 的成年人表现出前额外血液动力学反应的减少,特别是在前端. 这种大脑活动减少与ASD患者的注意力缺陷有关.

科学领域:

神经科学是一个神经科学.
发育神经科学的发展神经科学.
临床神经科学临床神经科学

背景情况:

功能神经成像表明,在自闭症谱系障碍 (ASD) 中,前额叶皮层功能障碍.
近红外光谱学 (NIRS) 非侵入性地测量大脑血液动力学反应.
之前的NIRS研究集中在患有自闭症的儿童身上,对成年人的研究有限.

研究的目的:

用NIRS.来研究ASD成年人的前额头血动力学反应.
探索前额活动和自闭症特征之间的关系.

主要方法:

在Stroop色词任务中,有114名患有自闭症的成年人和84名对照人接受了NIRS.
用24通道NIRS系统测量氧化血红蛋白的变化.
数据分析的重点是特定前额前部区域的血液动力学反应.

主要成果:

与对照人群相比,患有自闭症的成年人在轨道前皮层和前极表现出明显较小的氧化血红蛋白变化 (p < 0.05).
降低20通道的血液动力学反应与更高的自闭症谱系系数日本版 (AQ-J) 得分和注意力转换困难相关 (p = 0.043,p = 0.009).

结论:

患有自闭症的成年人通过NIRS.表现出减弱的前额外血液动力学反应.
在ASD中,前极活动减少与注意力功能受损有关.

关键词:

自闭症谱系障碍自闭症谱系障碍血动力学反应血动力学反应接近红外光谱学近红外光谱学前额叶皮层前额叶皮层草图色彩-字任务任务.

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相关概念视频

Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.