在患有慢性部和肩部疼痛的人中,脊柱体管中的局部异常白质微结构
Zhiqiang Qiu1, Tianci Liu1, Chengxi Zeng1
1Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Frontiers in neuroscience
|January 21, 2025
概括
慢性部和肩部疼痛 (CNSP) 与脊柱体管 (STT) 中微观结构性白质变化有关. 这些变化与疼痛强度和持续时间相关,为慢性疼痛机制提供了洞察力.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 疼痛研究 疼痛研究
背景情况:
- 慢性部和肩部疼痛 (CNSP) 显著影响生活质量.
- 脊髓管 (STT) 在疼痛信号传输中起着至关重要的作用.
- 了解STT中的白质微结构变化对于慢性疼痛研究至关重要.
研究的目的:
- 调查与健康对照对象相比,患有CNSP的个体的STT白质中的微结构差异.
- 评估STT白质完整性与CNSP患者疼痛强度/持续时间之间的相关性.
主要方法:
- 扩散张力成像 (DTI) 用3.0TMRI扫描仪对31名CNSP患者和24名健康对照 (HC) 进行.
- 使用自动纤维细分和量化 (AFQ) 方法提取和分析STT.
- 分数异构性 (FA) 和平均扩散性 (MD) 被量化以评估白质的微观结构完整性.
主要成果:
- 虽然总体上FA和MD在组之间没有显著差异,但STT的特定部分在CNSP组中显示出显著的微观结构异常.
- 与HC相比,在CNSP患者的左和右STT的特定部分观察到减少FA和增加MD.
- 受影响的STT区域的FA值与疼痛强度 (VAS分数) 和持续时间有负相关性,而MD值显示出正相关性.
结论:
- CNSP与STT内的特定白质微结构异常有关.
- 这些异常与疼痛强度和持续时间相关,这表明慢性疼痛病理生理学的作用.
- 这些发现为疼痛传导提供了神经成像的视角,但由于样本大小的限制,需要在更大的队列中进行验证.
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