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恶性质瘤患者的临床结果是否因性别而异?

Maria Goldberg¹, Laura-Sophie Frank², Ghaith Altawalbeh¹

¹Department of Neurosurgery, School of Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.

|January 21, 2025

概括

男人比女性更年轻地被诊断出恶性质瘤,但手术后的临床结果显示没有与性别相关的差异. 预后因素如年龄和治疗比性别更为重要.

科学领域:

神经瘤学神经瘤学
手术瘤学手术瘤学
流行病学流行病学

背景情况:

已知恶性质瘤流行病学的性别相关差异,但临床特征和手术结果需要进一步调查.
关于高度质瘤 (HGG) 管理和预后的性别差异的数据有限.

研究的目的:

调查高度质瘤患者临床特征和结果的性别特异性差异.
确定影响恶性质瘤患者生存的预后因素.

主要方法:

单一中心对621名经过手术的世卫组织第四级质瘤患者进行了回顾性研究 (2010-2020年).
统计分析包括千平方,独立样本t测试,曼-惠特尼U测试,日志排名和卡普兰-梅尔方法.
多变量分析评估了性别和其他因素对生存和并发症的影响.

主要成果:

男性在较年轻时被诊断出来,并且在诊断后更早地接受手术,手术并发症的发生率略高.
女性呈现出较差的手术前表现状况.
多变量分析显示,性别没有影响生存率,并发症,药物滥用或瘤体积;然而,年龄,表现状况,切除程度和用temozolomide进行辅助放射治疗改善了生存率.

结论:

虽然男性在较年轻时被诊断出患有恶性质瘤,但性别不会影响临床结果或生存率.
预后因素,如年龄,表现状况,手术切除和辅助疗法,对于生存来说比性别更为关键.

关键词:

无塑性小聚合物质质瘤扩散性星球细胞瘤是什么结晶性肉瘤 (gliosarcoma) 是一种癌症.高度质瘤高度质瘤性差异性差异性差异性差异性差异性差异性差异性

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