西拉贾斯坦邦维生素D水平的横截面研究和维生素D水平估计的元分析
Surjit Singh1, Divesh Jalan2, Pankaj Bhardwaj3
1Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, India.
Indian journal of clinical biochemistry : IJCB
|January 21, 2025
概括
维生素D缺乏在印度很常见. 这项研究建议治疗具有症状的个体,维生素D水平低于12.5ng/ml,而不是仅依靠一般人群的切断值.
科学领域:
- 内分泌学和新陈代谢学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏是全球普遍存在的健康问题,尤其在印度人口中普遍存在.
- 目前关于维生素D充足度的建议可能不准确地反映健康的印度成年人的正常生理水平.
- 建立特定人群的参考范围对于准确诊断和有效管理维生素D状况至关重要.
研究的目的:
- 为了确定18-60岁的健康印度成年人的正常血清25...OH) D水平.
- 建议适当的切断值来确定印度人口中维生素D缺乏的定义.
- 评估维生素D水平与其他骨健康标志物 (如,,iPTH和骨ALP) 之间的相关性.
主要方法:
- 涉及18-60岁健康的印度受试者的横截面研究.
- 血清,,iPTH,骨酸酶 (ALP) 和25(OH) D水平的生物化学测试.
- 对现有研究进行元分析,以确定印度人口中聚合平均维生素D水平.
主要成果:
- 在研究群体中,平均25(OH) D水平为13.5±7.83 ng/ml,从元分析中得出的综合平均值为13.95 ng/ml.
- 在血清25(OH) D和水平之间观察到显著的正相关性 (r=0.148,p=0.003).
- 该研究表明,在有症状的个体中,维生素D水平低于12.5ng/ml应该是治疗开始的主要标准.
结论:
- 这项研究提供了证据,表明健康印度人的正常维生素D水平低于以前一般指南所假设的水平.
- 不建议依靠已确定的RDA (20 ng/ml) 和EAR (16 ng/ml) 值作为在印度开始维生素D治疗的最终截止值.
- 对于有症状的个体,建议为12.5 ng/ml的值作为在印度背景下进行干预的更合适的标准.
关键词:
25 (((OH) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D)骨 ALP 是一个骨 ALP.是一种进行元分析分析.是一种的物质.维生素D 维生素D是一种维生素.在 iPTH 上,您可以使用 iPTH.更多相关视频
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