评估和对与预防药物治疗相关的输液反应进行比较
Jacob Noble1, Clay Irvine1, Amy Tevaarwerk1
1Mayo Clinic, Rochester, MN, USA.
概括
在塔克桑注射前30-80分钟服用预防药物显著减少了注射反应. 这种时间是降低反应可能性的最佳时间,而不会影响严重程度,允许大多数患者完成治疗.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 塔干化疗剂 (帕克利塔塞尔,多塞塔塞尔) 与过敏反应和输液反应的高发病率有关.
- 国家癌症研究所常用术语标准 (NCI CTCAE) 用于对这些反应进行分类.
- 预防药物,包括H1RAs,H2RAs,类固醇或组合药物,用于减轻因税诱导的输液反应.
研究的目的:
- 根据预防药物管理的时间来比较输液反应的发生率和严重程度.
- 为了确定最佳的预防性药前注射时间.
主要方法:
- 在2022年1月30日至2023年1月30日期间进行的纳税注射 (帕克利塔塞尔或多塞塔塞尔) 的回顾性审查.
- 输液被标记为审查,如果救援药物是必要的输液后启动.
- 对输液反应速率和严重程度与预防药物治疗时间相关的分析,包括按类型分类的子组分析.
主要成果:
- 在1486次总量注射中,249次已确认的注射反应使用NCI CTCAE进行了分级.
- 对于第一个和第二个税剂量 (N=536),确定了222个输液反应.
- 接收预防药物的患者在30分钟前的纳克桑输注较少可能经历输注反应 (p=0.037).
结论:
- 在第一和第二次纳注射前30到80分钟服用预防药物是最优的,以减少注射反应的可能性.
- 根据预防药物治疗时间,没有观察到输液反应严重性的显著差异.
- 大多数患者尽管经历了输液反应,但成功完成了他们的纳税注射,并根据需要使用救援药物.
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