中枢敏感化在自身免疫性结缔组织疾病中的作用:一个比较的横截面研究
Zilan Bazancir-Apaydin1, Hakan Apaydin2, Berkan Armagan3
1Department of Physiotherapy and Rehabilitation, Ankara Medipol University, Ankara, Türkiye.
International journal of rheumatic diseases
|January 21, 2025
概括
中枢敏感性 (CS) 在自身免疫结缔组织疾病 (ACTD) 中很常见,特别是Sjögren.
科学领域:
- 风湿病学和免疫学
- 神经科学是一个神经科学.
- 临床医学 临床医学
背景情况:
- 自身免疫结缔组织疾病 (ACTD) 可以表现为复杂的症状,包括与中央敏感化 (CS) 相关的症状.
- 了解ACTD中CS的患病率和特征对于有效的患者管理至关重要.
研究的目的:
- 调查诊断为自身免疫结缔组织疾病 (ACTDs) 的患者中中央敏感性 (CS) 的流行情况.
- 探索CS与各种临床因素之间的关系,如疾病活动,实验室发现,治疗,器官参与和并发症.
主要方法:
- 一项涉及111名患有ACTD (Sjögren综合征,类风湿性关节炎,全身性红斑狼) 的患者和40名健康对照者的研究.
- 通过使用中央敏感清单 (CSI-A和CSI-B分数) 评估中心敏感性.
- 所有参与者的疾病活动,实验室结果,治疗方法,器官参与和并发症都被系统地评估.
主要成果:
- 总的来说,41.4%的ACTD患者表现出CS的迹象.
- 斯乔格伦综合征 (SS) 的CS患病率最高 (58.3%),其次是类风湿性关节炎 (RA) (36.8%) 和全身性红斑狼 (SLE) (29.7%).
- CS评分与SLE中的维生素D3水平相关,以及SS中的叶酸和TSH水平. 具有较高CS分数的患者呈现出特定的临床特征,包括女性性别,呼吸系统疾病,纤维肌痛和较高的皮质类固醇使用.
结论:
- 中心敏感性是ACTD患者的常见发现,在Sjögren综合征中患病率明显更高.
- 在ACTD中CS与特定的实验室标记物有关,包括维生素D3,叶酸和TSH水平.
- 在ACTD群体中,表现出CS临床症状的患者具有独特的临床特征.
关键词:
斯乔格伦综合征 (Sjögren's Syndrome) 是一种疾病.中枢神经系统敏感化 敏感化慢性疼痛是一种慢性疼痛.类风湿性关节炎 类风湿性关节炎系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.更多相关视频
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