基于二硫化物化合物浸纸质基质的高效色度气体传感器,用于在非侵入性呼吸分析中检测挥发性硫化合物
Shuta Miura1, Kazuno Watanabe1, Akihiro Karashima1
1Tohoku Institute of Technology, 35-1 Yagiyama Kasumi-cho, Taihakuku, Sendai, Miyagi 982-8577, Japan.
ACS sensors
|January 21, 2025
概括
一个新的基于纸张的传感器可以检测呼吸中的挥发性硫化合物 (VSC),为诊断牙周病提供一种简单,非侵入性的方法. 这种具有成本效益的诊断工具为护理点应用提供了快速的结果.
科学领域:
- 分析化学 分析化学
- 生物医学诊断 生物医学诊断
- 材料科学 材料科学 材料科学
背景情况:
- 挥发性硫化合物 (VSC) 是牙周病的关键生物标志物.
- 非侵入性呼吸分析提供了一个有前途的诊断途径.
- 准确检测VSCs如甲基和硫化至关重要.
研究的目的:
- 为VSCs开发一种选择性和敏感的纸质气体传感器.
- 建立一种测色方法来量化VSC度.
- 评估传感器在临床诊断方面的潜力.
主要方法:
- 一种纤维素纸基板被浸了2.2'-dithiobis ((5-nitropyridine) 和酸.
- 在暴露于VSC时,使用分散反射光谱 (420nm) 分析了传感器的颜色变化.
- 库贝卡-蒙克 (K-M) 值和B/R比与VSC度相关.
主要成果:
- 传感器在VSC暴露时呈现出可逆的颜色变化,从白色到黄色.
- 在420nm和VSC度的K-M值之间建立了线性关系.
- 通过45ppb的甲基和7.1ppb的硫化检测极限,获得了高灵敏度.
结论:
- 开发的基于纸张的传感器提供了一种具有成本效益和简单的方法来检测VSC.
- 颜色测量分析可以进行定量VSC测量,适合临床应用.
- 这种传感器非常适合在VSC相关疾病的临床诊断,例如牙周病.
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