相关实验视频

Updated: Jun 1, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

优化带有伏利康纳的热敏水凝:in silico工具和ex vivo研究

Shama Parveen¹, Jasveer Kaur¹, Om Silakari¹

¹Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.

Drug development and industrial pharmacy

|January 21, 2025

概括

这项研究使用计算工具开发了一种带有voriconazole的热敏水凝,优化了聚合物和溶剂的选择. 由此产生的水凝表现出持续释放和有效的抗菌活性,对抗Candida albicans.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
计算化学计算化学

背景情况:

热反应性水凝为控制药物输送提供了潜力.
沃里康纳是一种重要的抗真菌剂,需要有效的输送系统.

研究的目的:

使用in silico工具开发和评估一个装有voriconazole的热反应性水凝.
优化聚合物和溶剂的选择,以实现高效的凝配方.

主要方法:

在使用Biovia Material Studio 2022进行凝聚性能量密度 (CED) 和溶解度参数 (SP) 计算的in silico研究.
预测聚合物-聚合物和药物-聚合物混合性.
在体外评估优化的水凝配方,包括针对Candida albicans的抗菌活性.

主要成果:

在 9:1 的比例下,Poloxamer 407 和 PEG 400 显示出最佳的混合性,以形成水凝.
优化的水凝表现出36.67°C的凝温度和良好的扩散性.
观察到药物持续释放超过36小时,并且在体外显著的抗微生物疗效.

结论:

在 silico 工具有效指导了 voriconazole 热反应性水凝的开发,最大限度地减少了实验代.
开发的水凝配方显示出有效的抗真菌药物递送的希望.

关键词:

沃里康纳 (Voriconazole) 是一种可以在学研究中.透性研究研究.释放动力学释放动力学局部热反应性水凝.

更多相关视频

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

Published on: January 14, 2020

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Published on: September 17, 2014

相关概念视频

Methods for Studying Drug Absorption: In vitro

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...