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对CXCR5循环DNA甲基化水平在自身免疫性风湿性疾病中的比较分析

Yiming Shi^1,2,3, Yingying Qin^1,3, Yunshen Li^1,2,3

¹Department of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Immunity, inflammation and disease

|January 21, 2025

概括

在自身免疫性类风湿性疾病中,CXC化学因子受体5 (CXCR5) 的DNA甲基化不同. 在类风湿性关节炎 (RA) 中,CXCR5甲基化与炎症标志物相关,可能有助于诊断.

科学领域:

免疫学免疫学免疫学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
类风湿病学类风湿病学

背景情况:

自身免疫性类风湿性疾病 (ARDs) 的特点是免疫系统的调节失调.
CXC化学因子受体5 (CXCR5) 在免疫细胞贩运中发挥作用.
表观遗传修饰,如DNA甲基化,涉及到ARDs.

研究的目的:

在ARD患者中调查CXCR5的循环DNA甲基化差异.
探索CXCR5甲基化与ARDs临床特征之间的关联.

主要方法:

针对性甲基化测序在周围血液样本上进行.
这项研究包括患有类风湿性关节炎 (RA),全身性红斑狼 (SLE),结性脊髓炎 (AS),牛皮关节炎 (PsA),Sjögren综合征 (SS) 和健康对照 (HC) 的患者.

主要成果:

在RA和HC之间以及AS和SLE之间观察到CXCR5cg19599951甲基化的显著差异.
关节炎患者的甲基化水平高于HC和AS,但低于SLE.
与HC,AS和PSA相比,SLE患者的甲基化水平较高.
在RA患者中,CXCR5甲基化和哈普洛型与红细胞沉积率 (ESR),C反应蛋白 (CRP),类风湿因子和抗林蛋白抗体水平相关.
通过CXCR5甲基化,可以区分RA和AS.

结论:

在ARD中存在不同的循环CXCR5甲基化水平.
CXCR5甲基化与RA中的炎症媒介有关.
CXCR5甲基化可能成为RA诊断的潜在生物标志物.

关键词:

在CXCR5中,CXCR5是CXCR5.通过DNA甲基化.自免疫性类风湿性疾病.循环中的甲基化水平.这是一种炎症炎症炎症炎症.

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