临床试验:精确的苏克拉酸盐粉末的管理,以预防延迟的多斑管切除术后出血. 一个随机对照试验
Hsueh-Chien Chiang1,2, Po-Jun Chen1, Er-Hsiang Yang1
1Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Clinical and translational gastroenterology
|January 21, 2025
概括
结肠镜喷苏克拉酸粉显著降低了结肠片去除后延迟出血. 这种安全的方法提供了一种有前途的策略,以预防多重切除术后的出血并发症.
科学领域:
- 胃肠病学 胃肠病学
- 内镜手术 进行内镜手术
- 预防手术并发症 预防手术并发症
背景情况:
- 术后延迟出血影响1-2%的患者,大息肉 (>2厘米) 则增加到6%.
- 糖酸盐以其粘膜保护和治疗特性而闻名.
研究的目的:
- 为了评估结肠镜中苏克拉酸盐粉末喷雾在预防延迟的多肉切除术后出血的疗效.
- 评估这种预防性干预措施的安全性和有效性.
主要方法:
- 一项随机对照试验,涉及160名接受结肠镜多斑切除术 (多斑大小≥0.5厘米) 的患者.
- 患者被随机分为两组:一组接受预防性糖酸粉喷雾 (3克) 在多斑瘤伤口上,和对照组.
- 两组都接受了标准治疗,即时出血,并在28天内监测出血延迟.
主要成果:
- 与对照组相比,糖酸盐组显示出延迟的多叶切除术后出血率 (0%对比6.3%,P=0.029) 和明显出血的便率 (2.4%对比18.8%,P=0.001) 显著降低.
- 在糖酸盐组中,无延迟出血的持续时间明显更长 (P=0.024).
- 多变量分析发现,糖酸喷雾剂作为一个独立的防护因子,可以防止术后明显出血的便 (RR=0.03,P=0.009).
结论:
- 结肠镜喷苏克拉酸粉是一种安全有效的方法,可以降低延迟多角切除术后出血的风险.
- 这种干预措施显示出作为预防性措施的潜力,以预防结肠镜多角切除术后的出血并发症.
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