慢性阻塞性肺部疾病中中气喘诱导的MRI评估的动态高通胀:SPIROMICS-HF研究
Xuzhe Zhang1, Christopher B Cooper1, Martin R Prince1
1From the Department of Biomedical Engineering (X.Z.) and Columbia Magnetic Resonance Research Center (CMRRC) (W.S.), Columbia University, New York, NY; Departments of Medicine (C.B.C., J.P.F.) and Radiology (J.P.F.), University of California at Los Angeles, Los Angeles, Calif; Department of Radiology, Weill Cornell Medicine, New York, NY (M.R.P.); Department of Radiology (M.R.P., S.M.D., S.J.), Department of Medicine (M.C.B., R.G.B.), Department of Epidemiology (R.G.B.), Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics (W.S.), and Institute of Human Nutrition (W.S.), Columbia University Irving Medical Center, 632 W 168th St, PH-17, New York, NY 10032; Department of Radiology (B.A.V., J.A.C.L.) and Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine (N.N.H.), Johns Hopkins University, Baltimore, Md; Department of Radiology, University of Michigan, Ann Arbor, Mich (P.P.A.); Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wis (D.A.B.); Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC (D.C.); Departments of Radiology, Medicine, and the Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa (E.A.H.); Sections on Cardiology and Geriatrics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC (D.W.K.); Division of Pulmonary, Critical Care, Sleep, and Allergy (J.A.K.) and Department of Radiology, College of Medicine (M.G.M.), University of Illinois at Chicago, Chicago, Ill; Department of Radiology and Biomedical Imaging (Y.J.L., J.L.), Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, School of Medicine (P.G.W.), and Cardiovascular Research Institute (P.G.W.), University of California at San Francisco, San Francisco, Calif; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Wake Forest University, Winston-Salem, NC (J.O., S.P.P.); Division of Pulmonary Medicine, Department of Medicine, Mayo Clinic, Phoenix, Ariz (V.E.O.); Department of Medicine, University of Utah, Salt Lake City, Utah (R.P.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.S.); Department of Radiology, Hannover Medical School, Hannover, Germany (J.V.C.); and BREATH, Member of the German Center for Lung Research (DZL), Hannover, Germany (J.V.C.).
实时肺部MRI可以可靠地测量慢性阻塞性肺病 (COPD) 的动态膨胀. 这种技术在严重的COPD中显示出更大的超通胀,有助于疾病评估.
科学领域:
- 医疗成像医学成像
- 肺部医学 肺部医学
- 心肺研究研究 心肺研究
背景情况:
- 慢性阻塞性肺病 (COPD) 是一种进展性肺病,其特点是空气流量受限.
- 动态膨胀,即呼吸时肺体积增加,是COPD的一个关键特征.
- 准确和可重复评估动态高通胀对于理解COPD严重程度和进展至关重要.
研究的目的:
- 为了评估实时电影肺部MRI的可重复性,以测量计量仪节奏分 (MPT) 诱导的动态膨胀.
- 调查MPT诱导的动态高通胀与慢性阻塞性肺病 (COPD) 严重程度之间的关联.
主要方法:
- 利用转移学习模型在实时电影肺部MRI扫描中进行精确的肺部细分.
- 通过测量在MPT期间末尾呼气肺体积 (EELV) 的增加来评估动态高通胀.
- 分析了使用类内相关系数的扫描-重新扫描协议,并检查了与COPD严重程度的关联.
主要成果:
- 转移学习模型在肺部细分方面表现出高精度 (迪斯系数,0.94).
- 对于EELV (ICC,0.99) 和动态高通胀 (ICC,0.87) 观察到非常好的扫描重复性.
- 动态高通胀与COPD严重程度有显著的相关性 (P趋势=0.01),在严重的COPD病例中水平更高.
结论:
- 一种基于转移学习的方法使MPT诱导的动态高通胀可以通过实时电影肺部MRI进行可重现的量化.
- 这种成像技术对评估COPD严重程度有希望,因为在患有更严重疾病的人群中观察到更大的动态膨胀.
相关概念视频
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Chronic Obstructive Pulmonary Disease-I: Introduction
Acute Respiratory Failure-III
Acute Respiratory Failure-IV


