图形模型选择以推断基因组预测中的等位基因效应的部分相关性网络与乳牛中的应用
Carlos A Martínez1, Kshitij Khare2, Syed Rahman3
1Departamento de Producción Animal, Universidad Nacional de Colombia, Bogotá, Colombia.
概括
我们开发了基因组预测的新统计方法,能够准确估计部分相关性网络和繁殖值. 这些方法识别了关键的基因组区域,提高了遗传洞察力和选择精度.
科学领域:
- 基因组学就是基因组学.
- 统计遗传学 统计遗传学
- 网络分析 网络分析
背景情况:
- 基因组预测模型通常假定标记效应的独立性,这可能会限制准确性.
- 估计遗传标记之间的复杂关系对于理解特征架构至关重要.
研究的目的:
- 开发和评估用于基因组预测的新型统计方法,以考虑标记效应的部分相关性.
- 从基因组数据估计部分相关性网络 (PCN) 和精度矩阵.
- 评估这些方法在预测育种价值和确定生物相关基因组区域方面的表现.
主要方法:
- 扩展了高斯度和定向非循环图模型的规范模型选择.
- 开发了集成EM算法的频率主义方法 (Glasso-EM,Concord-EM,CSCS-EM).
- 开发了贝叶斯的等级模型 (贝叶斯G-Sel,贝叶斯DAG-Sel).
- 将方法应用于公牛生育数据集,并进行模拟研究.
主要成果:
- 方法准确地恢复了PCN (高达0.98准确度与康科德-EM).
- 康科德-EM提供了最精确的矩阵估计.
- Glasso-EM实现了最高的育种价值预测可靠性 (0.85).
- 基于PCN的高连接性,确定了生物相关的基因组区域.
结论:
- 开发的方法有效地估计了部分相关性网络和精度矩阵.
- 在PCN中识别高度连接的基因组区域提供了生物学见解.
- 这些先进的统计方法提高了基因组预测的准确性和遗传发现.
更多相关视频
08:27Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
3.5K
09:35A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
Published on: August 16, 2017
17.8K
相关概念视频
01:49Multiple Allele Traits
34.0K
The Concept of Multiple Allelism
34.0K
01:35Pedigree Analysis
83.8K
Overview
83.8K
01:18Polygenic Traits
64.7K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
64.7K
01:06Heritability
189
Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic"...
189
01:11Genome-wide Association Studies-GWAS
12.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.4K
01:26Pharmacokinetic Models: Comparison and Selection Criterion
38
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
38