在重症监护研究中报告的复合初级结果:一个范围审查
Prashanti Marella1,2, Sansuka De Silva3, Antony G Attokaran4,5
1Department of Intensive Care Medicine, Caboolture Hospital, Caboolture, QLD, Australia.
Critical care explorations
|January 21, 2025
概括
复合初级结局 (CPO) 越来越多地用于重症监护研究,比单独的死亡率有优势. 然而,它们的定义和报告方法存在显著的变化.
科学领域:
- 关键护理医学 关键护理医学
- 临床试验方法论 临床试验方法论
- 健康研究成果研究结果
背景情况:
- 在重症监护研究中,复合初级结果 (CPO) 与基于死亡率的结果相比,具有优势.
- 探索和绘制CPO评估在重症监护的文献是必不可少的.
研究的目的:
- 探索和绘制在重症监护研究中评估的复合初级结果 (CPO) 的文献.
- 在重症监护研究中分析CPO的定义,趋势和报告.
主要方法:
- 从2000年到2024年,在多个数据库 (PubMed,Embase,CINAHL,Scopus,Cochrane) 进行系统的文献搜索.
- 包括所有研究类型 (RCT和非RCT) 在描述CPO定义的成年ICU中.
- 独立的双重选和数据提取,重点关注CPO特征,定义,趋势和死亡处理.
主要成果:
- 71项研究报告了17个不同的CPO,主要是药物试验 (67.6%) 使用RCT (84.5%).
- 最常见的CPO (40.8%) 是无呼吸器日,在定义和死亡处理方面表现出显著的变化.
- 在CPO定义,随访时间 (90天常见) 和统计方法 (频率主导) 中观察到异质性.
结论:
- 复合初级结果代表了重症监护研究中的新兴趋势.
- 在CPO定义,后续持续时间和报告实践中存在显著的异质性,需要标准化.
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