感染性内心炎患者的脊椎骨质炎:患病率,危险因素和死亡率
S Douiyeb1,2, K C E Sigaloff3,4, E G Ulas5
1Department of Internal Medicine, Amsterdam UMC location AMC, Amsterdam, The Netherlands. s.douiyeb@amsterdamumc.nl.
概括
感染性内心炎 (IE) 可能导致脊椎骨髓炎 (VO). 老年患者和肠球菌IE患者面临更高的VO风险,尽管死亡率相似.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 整形外科 整形外科 整形外科
背景情况:
- 传染性内心炎 (IE) 是一种严重的感染,影响心脏门和表面.
- 脊椎骨质炎 (VO) 是IE的潜在并发症,导致脊髓感染.
- 在IE患者中早期发现VO对于有效管理至关重要.
研究的目的:
- 确定患有IE的患者中发展VO的危险因素.
- 为了评估IE患者的6个月死亡率和复发率,有和没有VO.
主要方法:
- 从2016年9月到2022年10月,在两个医院进行了观察性研究.
- 根据ESC标准,包括633名可能或确定的IE患者.
- 用于确定 VO 的风险因素的多变量逻辑回归.
主要成果:
- 在IE患者中,VO被诊断在11.5%的患者中.
- VO的独立风险因素包括Enterococcus spp. 感染率 (OR 2.48) 和年龄的增加 (OR 1.04每年).
- 在具有或没有VO的IE患者之间的6个月死亡率没有显著差异 (21.9%与19.6%对比). 在VO组中复发率较高,但在统计学上不显著.
结论:
- 大约12%的IE患者会发展VO.
- 在老年患者和因Enterococcus物种引起的IE患者中,对脊椎感染的怀疑更高.
- 可能需要进一步的研究来澄清VO对IE复发率的影响.
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