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在结性脊柱炎中大动脉反 - - 一项心声回声监测后续研究

Karin Bengtsson^1,2, Georgios Mourtzinis^3,4, Anna Deminger^5,6

¹Department of Rheumatology and Inflammation Research, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. karin.bengtsson@gu.se.

Clinical rheumatology

|January 21, 2025

概括

大多数患有结性脊柱炎 (AS) 的患者在几年内经历了稳定的大动脉吐 (AR) 和近端上升大动脉 (PAA) 宽度. 在这个队列中,AR或PAA扩张的进展并不常见.

科学领域:

心脏病学心脏病学
类风湿病学类风湿病学
医疗成像医学成像

背景情况:

大动脉反 (AR) 和近道上升大动脉 (PAA) 扩张是结性脊髓炎 (AS) 的已知并发症.
在AS患者中,AR和PAA直径的长期进展仍未得到充分研究.

研究的目的:

在AS患者中评估AR和PAA直径的纵向过程.
为了确定AR和PAA维度在3-5年的随访期间的进展或稳定速度.

主要方法:

在52名AS患者 (最初187名) 进行了随访心声回声队列研究,在基线时具有或没有AR.
3-5年后,患者被重新检查,由独立观察员评估AR严重程度和PAA直径.
统计分析包括威尔科克森签名的等级和曼-惠特尼U测试,以评估PAA直径的变化.

主要成果:

在26名在基线有AR的患者中,大多数 (16/26) 显示不变的AR等级,而8/26的AR程度较小.
最初没有AR的两名患者在随访时发展出轻度AR.
PAA直径的平均变化为0毫米,没有统计学上显著的整体或子组增加.

结论:

大多数AS患者在3-5年的随访期间表现出稳定的AR和PAA直径.
这些发现表明,在AS患者中,AR进展通常缓慢.
在这个人群中,PAA扩张的显著进展似乎很少见.

关键词:

结性脊柱炎是一种疾病.大动脉的反.群组研究是一项群组研究.心声回声扫描 (Echocardiography) 是一种心声回声扫描.

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