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相关概念视频

Mechanism of Angiogenesis01:10

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
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微观多炎中的动脉瘤破裂:基于病例的综述

Keita Imanishi1,2, Kazuhiro Yasuo3, Yusuke Shirai4

  • 1Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Bunkyo-Ku, Tokyo, Japan. k.imanishi.jl@juntendo.ac.jp.

Clinical rheumatology
|January 21, 2025
PubMed
概括

微观多炎 (MPA) 可以导致动脉动脉瘤,动脉动脉瘤破裂导致显著的死亡率. 早期的免疫抑制治疗可以预防这些危险的破裂.

关键词:
动脉瘤是一个动脉瘤.中等血管血管炎.微观的多阳性炎.破裂 破裂 破裂 破裂

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科学领域:

  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 类风湿病学 类风湿病学
  • 血管外科 血管外科

背景情况:

  • 微观多管炎 (MPA) 是一种小和中型血管血管炎,可导致动脉动脉瘤.
  • 在MPA中破裂动脉瘤是罕见的,在本研究之前,只有15例英语文献报告的病例.
  • 这项研究调查了一例患有多重内脏动脉瘤的MPA致命病例,并审查了现有的文献,以了解MPA中的动脉瘤破裂.

研究的目的:

  • 分析微观多炎患者的动脉动脉瘤的临床特征,破裂特征和结果.
  • 确定MPA相关动脉瘤干预的风险因素和最佳时间.

主要方法:

  • 一个全面的审查16例破裂动脉瘤在MPA,包括一个致命的病例经历的作者.
  • 对器官干扰,动脉瘤位置,破裂时间,出现症状,病理发现和死亡原因的分析.
  • 临床表现与病理发现和治疗结果的相关性.

主要成果:

  • 常见的器官干扰包括血球膜炎 (100%),肺部 (25%) 和外围神经病变 (25%).
  • 破裂动脉瘤最常出现在左胃动脉 (31.25%),脏和肝脏动脉 (18.75%).
  • 症状出现后平均45天和免疫抑制治疗后15天发生破裂;死亡率为50%.

结论:

  • 与MPA相关的破裂动脉瘤通常最初呈现为限性血管炎,腹部中等大小的动脉容易破裂.
  • 动脉瘤通常无症状发展,并在症状出现或开始治疗后的几周内破裂.
  • 早期免疫抑制治疗对于潜在的缩小动脉瘤和预防MPA患者破裂至关重要.