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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
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塔克罗利慕斯和糖尿病动物模型.

Minyan Qian1,2, Mengmeng Guan1,2, Liying Wang1

  • 1Department of Pharmacy, The First People's Hospital of Changzhou/The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China.

Pharmacological reports : PR
|January 21, 2025
PubMed
概括

作为一种免疫抑制剂的塔克罗利斯 (TAC) 可以通过损害小岛贝塔细胞功能的方式引起糖尿病. 本综述总结了TAC诱导的糖尿病模型和潜在的治疗策略,以减轻这种不良影响.

关键词:
动物模型动物模型糖尿病是一种糖尿病.葡萄糖代谢障碍 葡萄糖代谢障碍鼠标 鼠标是一个鼠标.鼠标 鼠标 鼠标 鼠标塔克罗利慕斯可以使用.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 内分泌学 在内分泌学.
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 塔克罗利木斯 (TAC) 是器官移植中的重要免疫抑制剂.
  • TAC的一个显著不良影响是葡萄糖代谢障碍,增加糖尿病风险.
  • 了解TAC诱导的糖尿病机制对于预防和治疗至关重要.

研究的目的:

  • 系统地审查动物模型的Tacrolimus诱导的糖尿病.
  • 总结涉及TAC诱导糖尿病的关键分子通路.
  • 评估用于管理TAC诱导的葡萄糖代谢障碍的干预措施.

主要方法:

  • 在2024年8月19日之前,对PubMed索引的文章进行系统文献综述.
  • 分析了48项TAC诱导的糖尿病动物模型研究和22项糖尿病/肥胖模型中TAC影响的研究.
  • 根据TAC剂量,施用,持续时间和葡萄糖代谢指数进行总结.

主要成果:

  • TAC通过CaN/NFAT,PI3K/AKT/mTOR和TGF-β/Smad通路损害了岛屿β细胞的功能.
  • TAC诱导非肥胖的糖尿病模型模仿2型糖尿病和移植后糖尿病.
  • 降低剂量,停止使用和各种药理学药物可以调节TAC诱导的糖尿病.

结论:

  • 在移植中,TAC诱导的糖尿病是一个重大的问题.
  • 动物模型为糖尿病病原和治疗提供了宝贵的见解.
  • 这一审查指导了为未来研究选择合适的动物模型.