随着CAR-T细胞疗法的心脏毒性影响:文献综述
Tony Joseph1,2, Jimmy Sanchez1, Ahmed Abbasi3
1Department of Radiology, Albert Einstein College of Medicine and the Montefiore Medical Center, 111 East 210Th Street, Bronx, NY, 10461, USA.
Current oncology reports
|January 21, 2025
概括
化学抗原受体T细胞 (CAR-T) 治疗虽然对血液癌症有效,但具有显著的心脏毒性风险. 患有严重细胞因子释放综合征 (CRS) 的患者面临更高的心脏事件风险,需要进一步的长期研究.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 化学抗原受体T细胞 (CAR-T) 治疗是一种革命性的血液恶性瘤治疗方法.
- 卡特-T疗法与显著的副作用有关,特别是心脏毒性.
研究的目的:
- 审查有关CAR-T治疗相关心脏毒性的发病率,临床表现和风险因素的当前文献.
- 综合关于CAR-T心脏毒性的有限和异质研究的发现.
主要方法:
- 关于CAR-T心脏毒性的已发表研究的文献综述.
- 对临床表现,发病率和风险因素的分析.
- 检查心脏事件和心声回声检查结果.
主要成果:
- 卡特-T疗法与急性和亚急性心脏毒性的重大风险有关.
- 高度细胞因子释放综合征 (CRS) (2级或更高) 与心脏毒性风险增加有关.
- 常见的心脏事件包括低血压,低心率,心力衰竭,心律失常和心肌病变;心声图的变化涉及缩和放缩功能障碍.
结论:
- 卡尔-T心脏毒性是一个重大问题,需要仔细监测.
- 成人和儿科患者之间存在心脏毒性差异.
- 对于CAR-T治疗对心脏的长期影响仍然很大程度上是未知的,需要进一步调查.
关键词:
耳前心律不整 耳前心律不整血液中的生物标志物癌症免疫疗法癌症免疫疗法心肌病是一种心肌病.心脏有毒性 - 心脏有毒性细胞因子释放综合征 (CRS)扩张性功能障碍 扩张性功能障碍这是一个ECGECGECGECGECG.电脑心电图 (EKG) 是一种心电图.一个心声回声图 (Echocardiogram) 是一个心声回声图.血压下降 血压下降 血压下降热素 (TNT) 是一种更多相关视频
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