在韩国更年期的年龄和2型糖尿病的发展
Byung-Joon Ko1, Jin-Hyung Jung2, Kyungdo Han3
1Joon 365 Clinic, Hwaseong, Republic of Korea.
JAMA network open
|January 21, 2025
概括
更年期的年龄较小,特别是过早的更年期 (40岁前) 增加了绝经后妇女的2型糖尿病风险. 早期更年期与较高的T2D发病率有关,强调需要有针对性的预防策略.
科学领域:
- 内分泌学 在内分泌学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于更年期时的年龄与2型糖尿病 (T2D) 发病率之间的关联的证据有限.
- 了解这种联系对于识别风险人群和制定有针对性的干预措施至关重要.
研究的目的:
- 调查更年期的年龄,包括过早更年期,与韩国更年期后妇女T2D发病率之间的关联.
主要方法:
- 一项以人口为基础的队列研究利用了1,125,378名没有T2D的绝经后韩国妇女的数据.
- 多变量考克斯比例危险回归分析了基于更年期年龄的T2D事件风险.
- 随访时间中位数为8.4年,数据分析于2024年3月.
主要成果:
- 经历过过早更年期的女性 (年龄<40岁) 患T2D的风险增加了13% (HR,1.13;95% CI,1.08-1.18).
- 早期更年期 (40-44岁) 也与3%的T2D风险增加有关 (HR,1.03;95% CI,1.00-1.06).
- 一个显著的趋势显示,更年轻的绝经年龄与较高的T2D风险相关 (P < .001),BMI,抑郁症和糖尿病前期改变了这些关联.
结论:
- 过早和早期更年期与患T2D的风险显著增加有关.
- 这些发现强调了以预防或延缓绝经后妇女的T2D为重点的公共卫生策略的重要性,特别是那些更年期较早开始的女性.
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