与年龄相关的黄斑退化中的地理缩
Sandra Liakopoulos1, Leon von der Emde, Marvin L Biller
1Department of Ophthalmology, Cologne Image Reading Center (CIRCL), University of Cologne, Cologne, Germany; Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany; Department of Ophthalmology, University of Bonn, Bonn, Germany; GRADE Reading Center, Bonn.
Deutsches Arzteblatt international
|January 21, 2025
概括
目前,欧洲没有批准的治疗方法用于地理缩 (GA),一种与年龄相关的黄斑变性 (AMD). 对新疗法,包括基因疗法和微量营养素的研究正在进行中,而预防措施仍然至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 是一个遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 与年龄相关的黄斑变性 (AMD) 是不可逆转的视力丧失的主要原因.
- 地理缩 (GA),AMD的干燥后期阶段,涉及逐渐的中枢视网膜细胞损失.
- 据估计,GA在德国影响了30万到55万个人.
研究的目的:
- 审查目前和新兴的地理缩 (GA) 治疗方法.
- 评估最近GA疗法的疗效和监管状况.
- 突出预防和康复策略的持续需求.
主要方法:
- 在PubMed和Web of Science数据库中进行了选择性的文献搜索.
- 该审查综合了已批准和正在研究的GA治疗方法的发现.
- 研究了微量营养素和基因治疗干预措施的证据.
主要成果:
- 补充抑制剂Pegcetacoplan和avacincaptad pegol在2023年在美国被批准用于GA治疗.
- 欧洲药品管理局 (EMA) 人用药品委员会 (CHMP) 建议撤回这些药物的欧洲营销许可申请.
- 欧洲药物管理局指出,尽管缩进展缓慢,但缺乏临床相关的功能益处,基因疗法和微量营养素正在调查中.
结论:
- 目前在欧洲没有批准的地理缩 (GA) 治疗方法.
- 戒烟和均衡饮食等预防措施至关重要.
- 康复性辅助,如放大视觉辅助,对于晚期GA患者来说很重要.
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