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通过烯环氧化酶扰乱胆固醇/脂代谢 发生克里佐替尼 肝毒性

Hao Yan1, Xiangliang Huang1, Yourong Zhou1

  • 1Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|January 21, 2025
PubMed
概括

克里佐替尼 (crizotinib) 通过烯氧化酶 (SQLE) 积累扰乱脂质代谢,导致肝损伤. 甲双或特比纳可能有助于减少这种药物诱导的肝损伤.

关键词:
自自是自的过程.克里佐丁尼布 (crizotinib) 的使用方法肝毒性 肝毒性 肝毒性溶酶体功能障碍 溶酶体功能障碍这种类型的体脂质是体脂质.斯克瓦林环氧化酶的使用

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