血清阳性和血清阴性Sjögren病干眼之间有什么区别?
Karim Mohamed-Noriega1, Janett Riega-Torres2, Aldo Noé Ramírez-Paura1
1Departments of Ophthalmology; and.
Cornea
|January 21, 2025
概括
血清阳性斯乔格伦病 (SjD) 患者的非侵入性眼破裂时间 (NIBUT) 缩短,眼睛干燥疾病 (DED) 症状更严重. 血清阳性和血清阴性SjD患者都经历了类似的DED症状和生活质量的降低.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 斯约格伦病 (SjD) 是一种影响外分泌腺的自身免疫性疾病,经常导致干眼病 (DED).
- 区分血清阳性和血清阴性SjD对于理解疾病异质性和管理至关重要.
- 血清状况对SjD患者的DED患病率和严重程度的影响需要进一步调查.
研究的目的:
- 为了比较血清阳性和血清阴性Sjögren病 (SjD) 患者之间的干眼病 (DED) 的患病率和严重程度.
- 为了评估与SjD血清状况相关的特定DED诊断测试结果.
主要方法:
- 一项前性,比较的横截面队列研究包括80名符合SjD标准的患者 (55名血清阳性,25名血清阴性).
- 排除相关的Sjögren综合征,并进行全面的干眼测试.
- 使用概括估计方程来计算眼间相关性的统计分析.
主要成果:
- 在血清阳性和血清阴性SjD组之间,年龄或性别分布没有显著差异.
- 血清阴性SjD患者的阳性小唾液腺活检率较高,但焦点得分较低.
- DED的患病率相似 (92.7%vs. 84%),但血清阳性SjD显示显著减少了非侵入性撕裂破裂时间 (NIBUT) (6.6 ± 3.2s vs. 8.8 ± 2.4s).
结论:
- 血清阳性肖格伦病 (SjD) 与显著减少的非侵入性眼破裂时间 (NIBUT) 和趋向于更严重的干眼病 (DED) 症状有关.
- 血清阳性和血清阴性SjD患者都表现出高水平的眼部症状和与视觉相关的生活质量显著降低.
- 在血清阳性和血清阴性SjD之间,DED的患病率是可比的,这突显了SjD对眼睛表面健康的普遍影响.
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