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神经肌肉电刺激增加了微循环流在混合病因的腿部
Keith Gordon Harding1, Melissa Blow, Faye Ashton
1Keith Gordon Harding, Mb ChB, CBE, FRCGP, FRCP, FRCS, FLSW, is Professor Emeritus Cardiff University, Cardiff, Wales; Adjunct Professor Monash University Malaysia, Subang Jaya, Selangor, Malaysia; and Co-Founder and Editor in Chief of the International Wound Journal. Melissa Blow, BSc, is Principal Podiatrist, South East Wales Vascular Network, Aneurin Bevan University Health Board, Cardiff, Wales. Faye Ashton, BSc, is Vascular Research Nurse, Leicester Biomedical Research Centre, Glenfield University Hospital, Leicester, United Kingdom. David Bosanquet, MD, is Consultant Vascular Surgeon, South East Wales Vascular Network, Aneurin Bevan University Health Board. Acknowledgments: The authors acknowledge the assistance of Firstkind Ltd, Hawk House, Peregrine Business Park, Gomm Road, High Wycombe, United Kingdom HP13 7DL for sponsoring the study (grant ref: FSK-SPECKLE-001) and provided the NMES devices for the trial. Keith Harding has received payments for consulting work from Firstkind Ltd. The authors have disclosed no other financial relationships related to this article. Submitted November 28, 2023; accepted in revised form April 17, 2024.
间歇性神经肌肉电刺激 (NMES) 显著提高了腿部的微血管流量和脉动性. 在患有混合静脉和动脉疾病的患者中,这种疗法可增强伤床和周围皮肤的血液循环.
科学领域:
- 血管医学 血管医学
- 再生医学是一种再生医学.
- 生物医学工程 生物医学工程
背景情况:
- 混合静脉和动脉病因的腿部在伤口愈合方面存在复杂的挑战.
- 微血管功能受损是导致这些病愈合延迟的关键因素.
- 需要新的治疗方法来改善伤床的血液流动.
研究的目的:
- 为了研究常神经间歇性神经肌肉电刺激 (NMES) 的疗效.
- 为了确定NMES是否可以增加伤床和周围区域的微血管流量和脉动性.
- 评估NMES作为一种潜在的治疗腿部的结合静脉和动脉起源的治疗方法.
主要方法:
- 一项涉及七名患有混合病因的腿部的参与者的研究.
- 激光光斑对比成像用于测量微血管流量和脉动性.
- 在基线和NMES期间,以1Hz的频率对常神经进行测量.
主要成果:
- NMES显著增加了38%的伤床流量 (P = .023).
- 随着NMES的使用,周回流量增加了19% (P = .009).
- 脉动率在伤床 (214%,P = .017) 和周围 (122%,P = .014) 区域都显示出大幅增加.
结论:
- 间歇性神经肌肉电刺激在增加微血管流量方面是有效的.
- NMES显示出作为治疗腿部的治疗干预的潜力,具有结合静脉和动脉病因.
- 这些发现表明,NMES可以改善血液循环的动态,这对伤口愈合至关重要.
