在临床手部骨关节炎研究中,自我报告的疼痛调查问卷并不反映患者的经验
Coen van der Meulen1, Lotte A van de Stadt1,2, Féline P B Kroon3
1department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.
Rheumatology (Oxford, England)
|January 21, 2025
概括
在手部骨关节炎 (OA) 中使用问卷的疼痛评估通常与患者的回忆不同. 这突显了在手部OA临床试验中评估治疗有效性的潜在问题.
科学领域:
- 类风湿病学 类风湿病学
- 临床试验 临床试验
- 患者报告的结果
背景情况:
- 手部骨关节炎 (OA) 疼痛通常使用重复问卷进行评估.
- 这些问卷在捕捉患者回忆的疼痛经历方面的准确性尚不清楚.
研究的目的:
- 调查实时疼痛问卷变化与患者手部OA回忆中的疼痛之间的一致性.
- 评估临床试验对临床试验结果评估的影响.
主要方法:
- 使用了手部OA患者的HOSTAS队列和HOPE试验的数据.
- 使用澳大利亚/加拿大手部骨关节炎指数 (AUSCAN) 和回忆问题测量疼痛.
- 通过使用科恩的卡帕和百分比协议,比较了AUSCAN分数与回忆疼痛的变化.
主要成果:
- 在AUSCAN变化和回忆疼痛之间的一致性很低 (42%在HOSTAS中,47%在HOPE中).
- 患者经常回忆起的疼痛不同于AUSCAN得分所显示的 (例如,回忆起的"恶化"与改善的AUSCAN).
- 诸如抑郁和焦虑之类的心理健康因素并没有影响一致性.
结论:
- 通过AUSCAN重复测量疼痛往往与患者回忆的疼痛经历有所不同.
- 这种差异对手部OA临床试验中患者报告的疼痛结果的解释有重大影响.
相关概念视频
01:29Blood and Nerve Supply to the Bones
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
01:17Assessment of the Gastrointestinal System I: Subjective Data
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems related to...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems related to...