一种人类致病性汉塔病毒在分类学上多样化的动物水库中循环并流失
Samuel M Goodfellow1, Robert A Nofchissey1, Chunyan Ye1
1Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
PLoS pathogens
|January 21, 2025
概括
在新墨西哥州的小型哺乳动物中,Sin Nombre orthohantavirus (SNV) 广泛传播,而不仅仅是鹿鼠. 在多种物种中发现了传染性SNV,这表明汉塔病毒心肺综合征 (HCPS) 的传播风险更广泛.
科学领域:
- 病毒学 病毒学
- 生态生态学 生态生态学
- 流行病学 流行病学
背景情况:
- 骨髓炎病毒,包括Sin Nombre骨髓炎病毒 (SNV),在人类中引起汉氏病毒心肺综合征 (HCPS).
- 在美国西南部,SNV很普遍,死亡率很高.
- 虽然西部鹿鼠 (Peromyscus sonoriensis) 是一个已知的储库,但SNV的替代储库仍然未被确定.
研究的目的:
- 调查新墨西哥州小型哺乳动物种群中SNV的流行率和持续性.
- 为了确定SNV超出主要已知的宿主之外的潜在的替代储存库.
- 了解各种小型哺乳动物群体内SNV循环的动态.
主要方法:
- 在新墨西哥州的野生捕捞小哺乳动物中进行了广泛的SNV遗传调查.
- 在已知患者暴露的部位进行纵向捕获,以随着时间的推移监测SNV循环.
- 从多种小哺乳动物物种的各种组织和便样本中分离出活体SNV.
主要成果:
- 在27%的受访动物中检测到SNV遗传物质.
- 纵向研究显示,随着时间的推移,多种物种的SNV循环率很高.
- 从几种小型哺乳动物物种的组织和便中成功分离了传染性SNV,证实了新的储存库.
结论:
- 在新墨西哥州,SNV广泛分布,并被多种小型哺乳动物种类持续庇护.
- 这些替代水库可以容纳和释放传染性SNV,从而增加潜在的传播途径.
- 这些发现需要扩大监测和对新世界汉塔病毒宿主物种动态的重新评估.
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