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相关概念视频

MicroRNAs01:22

MicroRNAs

21.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.2K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

16.5K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.5K
Experimental RNAi02:15

Experimental RNAi

6.0K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.0K
RNA Interference01:23

RNA Interference

25.9K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
25.9K

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相关实验视频

Updated: Jun 1, 2025

mirMachine: A One-Stop Shop for Plant miRNA Annotation
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mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

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微RNA获得了一项强大的奖项

Yu Li1, Sijie Chen1, Hai Rao2

  • 1Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|January 21, 2025
PubMed
概括

微RNAs (miRNAs) 显示出对诊断和治疗的希望,因为它们在健康和疾病中的作用. 克服科学挑战是充分实现其临床潜力的关键.

关键词:
RNA生物学的RNA生物学生物标志物生物标志物癌症 癌症 癌症 癌症 癌症这是一个小RNARNA.治疗方法是一种治疗方法.

更多相关视频

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
00:09

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

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Method for the Isolation and Identification of mRNAs, microRNAs and Protein Components of Ribonucleoprotein Complexes from Cell Extracts using RIP-Chip
13:34

Method for the Isolation and Identification of mRNAs, microRNAs and Protein Components of Ribonucleoprotein Complexes from Cell Extracts using RIP-Chip

Published on: September 29, 2012

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相关实验视频

Last Updated: Jun 1, 2025

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

2.5K
A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
00:09

A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools

Published on: August 21, 2019

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Method for the Isolation and Identification of mRNAs, microRNAs and Protein Components of Ribonucleoprotein Complexes from Cell Extracts using RIP-Chip
13:34

Method for the Isolation and Identification of mRNAs, microRNAs and Protein Components of Ribonucleoprotein Complexes from Cell Extracts using RIP-Chip

Published on: September 29, 2012

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科学领域:

  • 分子生物学分子生物学
  • 遗传学 遗传学是一种遗传学.
  • 生物化学 生物化学

背景情况:

  • 微RNA (miRNA) 是小型非编码RNA,在基因调节中起着关键作用.
  • 微RNAs的失调与各种生理和病理过程有关.
  • 新出现的证据突出显示了miRNAs的诊断和治疗潜力.

研究的目的:

  • 审查miRNAs的发现,生物发生和功能.
  • 探索miRNAs在诊断和治疗方面的临床应用.
  • 讨论miRNA研究当前的挑战和未来的方向.

主要方法:

  • 关于miRNA研究近期进展的文献综述.
  • 关于miRNA发现,生物发生和功能信息的综合.
  • 对miRNAs当前和潜在的临床应用进行分析.
  • 确定该领域的科学和技术挑战.

主要成果:

  • 在正常和疾病状态下,miRNAs是基因表达的关键调节者.
  • 在了解miRNA生物学和功能方面取得了重大进展.
  • 毫米RNA为非侵入性诊断和向治疗提供了有前途的途径.
  • 在将miRNA研究转化为临床实践方面,仍然存在一些科学和技术障碍.

结论:

  • 毫米RNAs代表了一个快速发展的领域,具有重大的临床前景.
  • 需要进一步的研究来克服现有的挑战,并充分利用miRNA的能力.
  • 基于miRNA的诊断和治疗方法的发展是未来的关键方向.