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Updated: Jun 12, 2026

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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在HIV-1包膜形状可塑性背景下评估bnAb功效

Caio Foulkes1, Nikolas Friedrich1, Branislav Ivan1

  • 1Institute of Medical Virology, University of Zurich (UZH), Zurich, Switzerland.

PLoS pathogens
|January 21, 2025
PubMed
概括

艾滋病毒-1广泛中和抗体 (bnAbs) 对不同的病毒Env构造表现出不同的效力. 一个新的面板,SENSE-19,揭示了对Env中间体的不同bnAb耐受性水平,提供了对其功能和中和范围的见解.

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Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...