临床验证MyProstateScore 2.0 测试使用首次捕捉的非数字直肠检查尿液
Jeffrey J Tosoian1,2, Yuping Zhang3, Jacob I Meyers4
1Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.
The Journal of urology
|January 21, 2025
概括
使用非DRE尿液的MyProstateScore 2.0 (MPS2) 测试可以准确检测高度前列腺癌. 与现有方法相比,这种方便的测试显著减少了不必要的活检.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 18基因的MyProstateScore 2.0 (MPS2) 测试之前需要进行数字后直肠检查 (DRE) 尿液.
- 提高前列腺癌检测的可访问性至关重要.
研究的目的:
- 为了验证MPS2测试使用首次捕获,非DRE尿液检测等级组 (GG) ≥2前列腺癌.
- 评估非DRE MPS2测试在减少不必要的活检中的临床实用性.
主要方法:
- 在活检前从266名男性收集了第一次捕获的尿样.
- 使用仅生物标志物,生物标志物+临床因素和生物标志物+临床因素+前列腺体积模型计算MPS2得分.
- 对PSA和前列腺癌预防试验风险计算器 (PCPTrc) 的MPS2性能比较,用于检测GG ≥2癌症.
主要成果:
- 与PSA (57%) 和PCPTrc (62%) 相比,MPS2模型在GG ≥2癌症检测 (71-77%) 中显示了曲线下的优越面积 (AUC).
- 通过MPS2测试,可以避免36-42%的不必要的活检,远远超过PCPTrc (13%).
- 对于以前有负面活检的患者,MPS2避免了44-53%的重复活检,而PCPTrc的2.6%.
结论:
- 第一次捕获,非DRE尿液MPS2测试保持高灵敏度GG≥2前列腺癌检测.
- 非DRE MPS2提供了一种方便,客观和准确的方法来降低 PSA 升高的男性的前列腺活检率.
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