稀土元素欧和对斑马鱼发育和运动能力的毒性
Boyu Yang1, Luning Sun2, Zheng Peng1
1Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Changsha 410012, China.
Journal of hazardous materials
|January 21, 2025
概括
稀土元素如欧和萨马会损害斑马鱼的发育和运动. 这些元素破坏基因表达,导致形,并损害游泳,突出显示潜在的人类健康风险.
科学领域:
- 环境毒理学环境毒理学
- 发展生物学 发展生物学
- 生态毒理学 生态毒理学
背景情况:
- 稀土元素 (REEs) 对技术至关重要,但它们的环境释放引发了健康问题.
- 了解REE毒性对于风险评估和管理至关重要.
研究的目的:
- 为了研究欧洲 (Eu) 和 (Sm) 暴露对斑马鱼的发育和运动效应.
- 阐明REE引起的毒性背后的分子机制.
主要方法:
- 斑马鱼幼虫暴露于Eu和Sm.
- 评估了发育参数 (心率,生长,形态) 和运动行为.
- RNA测序 (RNA-Seq) 分析了基因表达的变化.
- 光成像和阿克里丁色染色评估了器官生成和亡.
主要成果:
- 暴露于Eu和Sm会导致心率下降,生长抑制和形态形.
- 观察到与生物过程相关的基因表达的显著变化.
- 肝脏和胰腺器官发生障碍和亡的增加得到证实.
- 机动活动 (冲动和自发游泳) 严重受损,距离,频率和速度降低.
- 氧化酸化的下调和内在亡途径的上调是关键发现.
结论:
- 欧和萨马会导致斑马鱼的显著发育和运动缺陷.
- 暴露于REE会破坏关键的生物通路,包括能量代谢和亡.
- 调查结果强调了REEs对健康的潜在风险,并为环境风险评估提供了信息.
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