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Updated: Jun 1, 2025

Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
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Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue

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对蛋白质翻译后修改的全面分析显示,在肝细胞癌中,PTPN2-STAT1-AOX轴介导的瘤进展

Junli Wang1, Yu Lou2, Xiaojun Peng3

  • 1Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Translational oncology
|January 21, 2025
PubMed
概括

这项研究探讨了肝细胞癌 (HCC) 的翻译后修饰 (PTM),揭示了酸化和无处不在的关键变化. 这些PTM及其交叉通话为HCC药物开发提供了潜在的新目标.

关键词:
在CDK2中使用CDK2.基因组合物 基因组合物肝癌是一种肝癌.后翻译修改后的修改.蛋白质基的蛋白质基体是什么

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Author Spotlight: Enhanced Histone PTM Isomer Identification Through LC-TIMS-ToF MS/MS and PASEF05:52

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相关概念视频

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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