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电坚固,可生物降解,生物活性和纳米结构接,以加速慢性伤口愈合

Yiran Li¹, Hongxing Xu², Wenwen Zhao³

¹College of Textiles & Clothing, Qingdao University, Qingdao 266071, People's Republic of China.

|January 21, 2025

概括

这项研究通过结合电和热拉伸来开发了先进的聚-乳酸 (PLLA) sutures,并结合了草药化合物 (SRHC) 来增强伤口愈合. 这些生物活性具显示出治疗慢性糖尿病伤口的巨大潜力.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
手术创新在外科创新.

背景情况:

慢性伤口治疗需要具有增强生物功能的先进手术.
现有的往往缺乏有效愈合所需的特性,特别是在糖尿病伤口等复杂病例中.

研究的目的:

开发强大的,可生物降解和生物活性的聚L-乳酸 (PLLA) 纳米纤维.
通过结合Salvia miltiorrhiza Bunge-Radix Puerariae草本化合物 (SRHC) 来增强 suture 的生物功能.
评估这些新型 sutures 在促进慢性伤口愈合,特别是在糖尿病模型中的有效性.

主要方法:

使用改性电和热拉伸制造PLLA纳米纤维.
在电过程中将SRHC封装到PLLA纳米纤维中.
结构,机械性能和生物活性 (抗氧化剂,抗炎药物) 的表征.
使用人类皮肤纤维细胞 (HDF) 的体外细胞研究和使用糖尿病小鼠伤口模型的体内研究.

主要成果:

无珠,高度对齐的PLLA纳米纤维接成功地制造了SRHC或没有SRHC,在形态或结晶性上没有显著的变化.
用SRHC加载的部表现出增强的拉力和结结强度,改善的抗氧化和抗炎性质,以及剂量依赖的效果.
实验室研究表明,接促进了HDF的迁移,附着和繁殖.
在体内研究表明,与商业相比,高SRHC PLLA显著加快糖尿病伤口愈合,改善原沉积,新血管化和毛囊再生.

结论:

集成的电和热拉伸技术为生产先进的PLLA纳米纤维提供了可行的策略.
纳入SRHC显著提高了PLLA sutures的生物活性和伤口愈合潜力.
这些可生物降解,生物活性线显示出对难以愈合的慢性糖尿病伤口的有效治疗有很大的希望.

关键词:

生物功能生物功能糖尿病的伤口电力旋转是指电力旋转.纳米纤维线的使用外科手术 suture 手术 suture 的使用方法

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