肠道微生物群:在毒性中发挥关键作用 - - 对疾病,干预措施和联合暴露于有毒物质的影响
Zahra Shamsipour Nehzomi1, Kobra Shirani1
1Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
概括
暴露于会破坏肠道微生物群,增加疾病风险. 针对肠道健康的干预措施是有希望的,但结合的有毒物质会放大负面影响.
科学领域:
- 环境毒理学环境毒理学
- 微生物学 微生物学
- 人类健康 人类健康 人类健康
背景情况:
- (Cd) 是来自工业活动的有毒重金属污染物.
- Cd在体内累积,导致器官损伤,糖尿病和癌症.
- 肠道是口服Cd的主要目标,导致氧化应激和炎症.
研究的目的:
- 审查暴露对肠道微生物群的影响.
- 探索Cd诱导的肠道失调与各种疾病之间的联系.
- 讨论潜在的干预措施和组合毒性物质的影响.
主要方法:
- 对毒性和肠道微生物群的研究的文献综述.
- 对Cd对微生物结构,组成和功能影响的研究分析.
- 检查有关Cd暴露的健康结果和干预措施的研究.
主要成果:
- 暴露于Cd会改变肠道微生物群的多样性和组成,影响新陈代谢.
- Cd诱导的肠道失调与糖尿病,肥胖,心血管疾病和神经退行有关.
- 对Cd和其他有毒物质 (如微塑料) 的联合暴露加剧了肠道毒性.
结论:
- 显著破坏肠道微生物群的恒温,导致系统性健康问题.
- 针对肠道微生物群提供了针对Cd毒性的潜在治疗策略.
- 需要进一步的研究,以了解协同作用的毒性影响,并制定有效的干预措施.
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