肺移植和骨健康:一个叙述性回顾
Anna M Rzepka1, Lianne Tile2, Chung-Wai Chow3
1Department of Medicine, University Health Network and Sinai Health System, University of Toronto, Toronto, Ontario, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
概括
肺移植接受者面临高水平的骨质疏松症和骨折风险,特别是在手术后的一年. 有效的药理管理和抵抗训练对于改善骨健康和预防骨折至关重要.
科学领域:
- 肺部医学 肺部医学
- 内分泌学 在内分泌学.
- 整形外科 整形外科 整形外科
背景情况:
- 肺移植患者的骨健康状况未经审查,目前的指导意见有限.
- 骨质疏松症影响30-50%的候选人由于潜在的肺部疾病,生活方式和皮质类固醇使用.
- 移植后使用类固醇会导致骨质损失,需要谨慎管理.
研究的目的:
- 为提供肺移植骨健康的全面审查.
- 总结这一群体中骨病的流行病学,表现和管理.
- 突出需要改进的指导方针和进一步的研究.
主要方法:
- 对有关骨健康和肺移植的现有文献进行叙述性审查.
- 对骨质疏松症患病率,骨折发生率和管理策略的数据分析.
- 关于药理疗法和运动干预措施的证据综合.
主要成果:
- 骨质疏松症在肺移植候选人和接受者中普遍存在.
- 移植后骨折风险增加,脊椎和肋骨骨折很常见.
- 对于最佳的药理学管理存在有限的证据;抵抗训练显示出有前途.
结论:
- 肺移植接受者具有显著的骨质疏松症和骨折风险.
- 进一步的研究和正式的指导对于最佳的骨健康管理至关重要.
- 需要综合的方法,包括药物治疗和运动.
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