专科医生应该知道什么关于免疫检查点抑制剂及其副作用?
Viktor Yordanov Zlatkov Aleksandrov1, Fernando Martínez Sagasti1, Juncal Pérez-Somarriba Moreno1
1Hospital Clínico San Carlos, C. Profesor Martín Lagos SN, Madrid, 28040, Spain.
Medicina intensiva
|January 21, 2025
概括
免疫检查点抑制剂 (ICI) 可以改善癌症的生存率,但会引起与免疫相关的不良事件 (irAE),往往需要密集护理. 本综述研究了ICI患者的严重IRAE和独特感染.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 免疫检查点抑制剂 (ICI) 在过去十年里改变了癌症治疗.
- 虽然提高了生存率,但ICI治疗与显著的免疫相关不良事件 (irAE) 有关.
研究的目的:
- 审查经常需要进入重症监护室 (ICU) 的IRE.
- 探索接受ICI治疗的患者的传染性并发症.
主要方法:
- 文献审查侧重于导致ICU入院的irAEs.
- 分析ICI治疗患者的传染性负担.
主要成果:
- 某些irrAEs通常需要ICU入院,增加患者的发病率和死亡率.
- 在ICI治疗的患者面临来自免疫抑制和独特免疫失调的传染性风险.
结论:
- 了解和管理严重的IRE和相关感染对于ICI治疗至关重要.
- 需要进一步的研究来解决ICI诱导的免疫失调所带来的特定传染性挑战.
相关概念视频
Cytotoxic T Cells-mediated Immune Response
836
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
836
Tumor Immunotherapy
467
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
467
Immunodeficiency Diseases
897
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
897
Immune Response Against Viral Pathogens
735
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
735
Cell-mediated Immune Responses
66.8K
Overview
66.8K
Drugs Used in Lower Respiratory Disorders: Overview
349
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
349


