作为口腔白血病恶性转变的预测因素的DNA ploidy 状态:系统审查和元分析
Nandisha Thakkar1, Deepa R Mane1, Punnya V Angadi1
1Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences and Hospital, Constituent Unit of KLE Academy of Higher Education and Research, Belgaum, Karnataka India.
Oral surgery, oral medicine, oral pathology and oral radiology
|January 21, 2025
概括
在口腔白血病 (OL) 中的DNA无积分状况预测恶性转变 (MT). 与双胞胎OL相比,形OL显示MT风险增加了14.10倍,这表明了新的分级系统.
科学领域:
- 口腔病理学 口腔病理学
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
背景情况:
- 口腔白血病 (OL) 是一种潜在的恶性疾病.
- 准确评估恶性转变 (MT) 风险对于患者管理至关重要.
- 反映DNA含量的体状况是预测OL进展的潜在生物标志物.
研究的目的:
- 系统地审查和综合现有关于DNA ploidy在评估OL中MT风险中的作用的文献.
- 为了确定DNA化分析是否可以可靠地预测口腔白血病病例中的恶性转变.
主要方法:
- 在PROSPERO (CRD42022340184) 中注册的系统文献审查.
- PECO框架:患有OL,形状,双形状和MT的患者.
- 搜索了Scopus,PubMed和谷歌学者;使用修改后的REMARK工具评估了偏见风险.
- 使用森林地块进行了元分析,并评估了使用道地块 (95% CI) 的出版偏差.
主要成果:
- 口腔白血病与形形状表现出75.20%的MT风险.
- 在OL的二倍性病变中,MT的风险为8%.
- 与双胞胎OL相比,形OL的MT危险比率增加了14.10倍.
结论:
- 有证据支持检测DNA形状作为OL中MT的预测因子.
- 提出了一个分级系统:低风险 (二倍体质 + 轻度/中度发育不良) 和高风险 (二倍体质 + 严重发育不良 / 任何形体质损伤).
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