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使用大规模人口数据对饮食偏好和子宫内膜异位症风险的因果分析

Xin Cheng¹, Dan Ma¹, Xiuhong Wang¹

¹Department of Gynaecology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, 228 Jingui Road, Xianan District, Xianning, 437100, China.

Scientific reports

|January 21, 2025

概括

的消费可能会防止子宫内膜异位症 (EM),而咖啡和汁的偏好与增加的EM风险有关. 这项研究探讨了饮食与子宫内膜异位症发展的联系.

科学领域:

生殖医学生殖医学
营养流行病学营养流行病学
遗传流行病学遗传流行病学

背景情况:

饮食因素越来越多地被认为是它们在子宫内膜异位症 (EM) 发病过程中的潜在作用.
有限的研究已经研究了特定的饮食偏好和EM之间的因果关系.
了解这些联系对于潜在的饮食干预在EM管理中至关重要.

研究的目的:

使用孟德尔随机化 (MR) 调查187种饮食偏好和子宫内膜异位症之间的因果关系.
为了确定可能增加或减少患子宫内膜异位症的风险的特定饮食因素.
为预防和管理子宫内膜异位症的饮食修改提供基于证据的见解.

主要方法:

利用两个样本的孟德尔随机化 (MR) 分析与来自欧洲参与者的全基因组关联研究 (GWAS) 数据.
分析了超过50万个人的饮食偏好和64,658名子宫内膜异位症患者的数据.
采用逆方差加权 (IVW) 分析,使用错误发现率 (FDR) 对多次测试进行校正,以及异质性,性,留出一项和反向MR分析的稳定性.

主要成果:

青菜偏好显示出对所有阶段的子宫内膜异位症有显著的保护作用 (ASRM 1-4).
对咖啡和汁的偏好与患子宫内膜异位症的可能性增加有关.
亚组分析证实了在各种EM亚型中的保护作用,而咖啡和汁的偏好与特定的,更严重的EM形式有关.

结论:

青的偏好是对子宫内膜异位症的重要保护因素.
喜欢咖啡和汁可能会增加子宫内膜异位症的风险.
这些发现强调了饮食选择对子宫内膜异位症风险的潜在影响,并建议饮食管理策略的途径.

关键词:

草是一种草.在咖啡咖啡咖啡咖啡咖啡咖啡咖啡饮食中的饮食饮食.子宫内膜异位症是什么?子宫内膜异位症是什么?门德尔的随机化汁是一种汁.

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