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A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators
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肉毒神经毒素利用宿主消化蛋白酶通过激活OrfXs/P47来增加它们的口服毒性

Linfeng Gao1, Maria Barbara Nowakowska2, Katja Selby2

  • 1Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.

Nature structural & molecular biology
|January 21, 2025
PubMed
概括

orfX基因集群组件 (OrfXs和P47) 增强了小鼠的肉毒神经毒素 (BoNT) 口服毒性. 对OrfX2的蛋白质分解激活及其与NTNH的结合对于这种增强的毒性至关重要.

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