系统性血管炎与潜在的结核感染和相关因素:一个横截面的多中心研究
Jingjing Zhong1, Yuanchun Li1, Yan Chen1
1Division of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Clinical rheumatology
|January 21, 2025
概括
潜在结核感染 (LTBI) 在全身性血管炎患者中很常见,阳性率为31.4%. 贝希特综合征和吸烟史是关键的危险因素,需要在治疗期间进行有针对性的查.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- 系统性血管炎患者面临潜在结核病感染 (LTBI) 的风险增加.
- 关于这一特定患者群体中LTBI患病率和相关风险因素的数据有限.
- 了解系统性血管炎中的LTBI对于有效的管理和预防策略至关重要.
研究的目的:
- 用T-SPOT.TB.来确定系统性血管炎患者中LTBI的阳性率.
- 在这个人群中确定与LTBI相关的独立风险因素.
- 在系统性血管炎中为临床实践提供关于LTBI查的信息.
主要方法:
- 一项涉及13家中国医院的191名系统性血管炎患者的多中心,横截面研究.
- 使用T-SPOT.TB测定作为LTBI的主要查工具.
- 使用统计分析,包括多变量回归来确定风险因素.
主要成果:
- 系统性血管炎患者的整体LTBI阳性率为31.4%.
- 贝切特综合征 (BD) 呈现出最高的阳性率 (37.7%).
- 阳性T-SPOT.TB结果的独立风险因素包括吸烟史和BD;淋巴细胞数量下降和高剂量葡萄糖皮质激素使用与负面结果有关.
结论:
- 在全身性血管炎患者中,特别是那些患有BD或有吸烟史的患者中,LTBI很普遍.
- 在系统性血管炎的诊断和治疗期间,建议使用T-SPOT对LTBI进行查.
- 临床特征,如淋巴细胞计数和皮质类固醇剂量影响T-SPOT.TB结果,指导查策略.
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